FACT: FACT:

Advil® demonstrates a low risk of serious GI events

Stomach Stomach

THE GI SAFETY PROFILE OF ADVIL

Clinical studies have shown that when OTC ibuprofen is taken as directed by the label for no longer than 10 days, there is a very low increased risk of stomach complaints or bleeding.2-5 

  • A recent literature review found that in OTC doses of ibuprofen, there was a consistently low risk of serious GI events and that non-serious GI events are probably reversible upon cessation of the drug2
  • An epidemiologic study by Lewis et al and a systematic review by Henry and McGettigan found no significant increased risk of serious upper GI toxicity at doses <1200 mg daily6,7
  • In a study by Moore et al, only 4% of subjects taking OTC ibuprofen for 1 to 7 days reported a significant digestive system adverse event8
  • Studies have demonstrated that higher doses of ibuprofen are associated with a greater risk of GI side effects (odds ratio 4:6) vs lower (OTC) doses (odds ratio 1:1)2,6 

SAFETY INFORMATION FOR YOUR PATIENTS

As indicated in the Advil Drug Facts, ibuprofen, like all NSAIDs, may cause severe stomach bleeding. Risk of stomach bleeding increases if patients: 

  • Consume 3 or more alcoholic beverages per day 
  • Are aged 60 or older 
  • Are taking anticoagulants or steroids 
  • Are taking other drugs containing NSAIDs 
  • Have a history of stomach bleeding, ulcers, or other bleeding problems 
  • Take more than directed or for longer than directed (taking ibuprofen at higher doses than the approved OTC dosing and/or for longer than 10 days also increases this risk)