Advil® demonstrates a high overdose safety margin compared with Tylenol®1
The observed toxic dose for ibuprofen is 48 g vs 10 g for acetaminophen. That translates to 240 tablets of Advil 200 mg vs 20 tablets of Tylenol® Extra Strength 500 mg.
Thus, Advil has a wide therapeutic margin. Signs of acute overdose have been observed at 40x the maximum daily dose of ibuprofen.1
COMPARISON OF ADVERSE EVENTS (AEs) IN OVERDOSE BETWEEN ADVIL AND TYLENOL®
AEs observed with ibuprofen overdose include GI disturbance, CNS depression, and acute renal failure. Symptoms appear within 4 hours, are largely reversible with supportive therapy, and display a low risk of long-term effects.2
AEs observed with acetaminophen overdose include hepatotoxicity and require at least 24 hours to develop.1 Acetaminophen overdose can lead to liver failure and death1,3,4:
- There are 78,000 emergency department visits annually for non-abuse–related acetaminophen overdose3
- There were 1500 deaths from accidental acetaminophen overdose reported between 2001 and 2010 in the United States1
PREVALENCE OF LIFE-THREATENING AEs
In a study that compared the effects of aspirin, acetaminophen, and ibuprofen in overdose, there were prolonged, severe, or life-threatening symptoms reported in 5.4%, 5.2%, and 1.6% of adult patients, respectively.4
PERCENTAGE OF PATIENTS EXPERIENCING PROLONGED, SEVERE, OR LIFE-THREATENING SYMPTOMS IN OVERDOSE4
A large-scale review article concluded that, when compared with all analgesics, OTC ibuprofen is less toxic in serious overdose situations and is rarely associated with death from either accidental or intentional overdose (or with serious adverse events).5
Additionally, ibuprofen has no potential drug dependency or narcotic side effects.1
SAFETY MARGINS OF OTC ANALGESICS1
*Calculated based on 60 kg individual.
†The higher the number, the wider the drug’s margin of safety.