FACT: FACT:

The medicine in Advil® has a low risk factor for developing renal conditions1-3

Kidney

RENAL ADVERSE EFFECTS AT OTC DOSES

A well-controlled clinical trial (N=25) and an epidemiologic study with a total of 1574 patients receiving ibuprofen indicate that the frequency of kidney function–related adverse events with OTC doses of ibuprofen is low.3,4

A double-blind study evaluating the renovascular effects of OTC ibuprofen in elderly hypertensive patients with mild renal impairment found that ibuprofen did not appear to be a risk factor in the development of additional renal compromise or the diminishing of hypertension control (N=25).

RENAL ADVERSE EFFECTS AT Rx DOSES

NSAIDs, including ibuprofen, demonstrate an increased risk of causing renal impairment at high (Rx) doses, especially among elderly patients or patients with reduced renal function.

Serious renal pathology has been rarely seen with ibuprofen use. These reactions have not been observed in OTC ibuprofen trials.1,2,6

 

SAFETY INFORMATION FOR YOUR PATIENTS

The Advil Drug Facts recommend that patients with kidney disease or who are taking a diuretic should consult a doctor before use.